Chromosomal alterations have been the focus of interest, since, during the evolution of the tumor in cells subjected to conditions of high extra and intracellular stress, the early emergence of rearrangements in the genetic material may favor clones that are more suitable for tumor survival. These chromosomal changes, product of chromosomal instability (INC) inherent to the metabolic stress of the tumor cell, can favor the acquisition of distinctive features that promote tumor proliferation and evolution, such as: 1) maintenance of proliferation signaling; 2) avoidance of growth suppressors; 3) resistance to cell death; 4) replicative immortality capacity; 5) induction of angiogenesis; 6) invasion and metastasis; 7) reprogramming of metabolism; and 8) evasion of the immune response. Our research group is interested in conducting a search for chromosomal regions that may be decisive in the content of critical genes in tumor pathology.