Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.
Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes.
Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus.
During hippocampal neuron differentiation, the expression of critical inducers of non-neuronal cell lineages must be efficiently silenced.
Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts.
Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified,…
En el mundo, el cáncer de pulmón es la principal causa de muerte por neoplasias, yello se debe a que su detección ocurre en los estadios más avanzados de la enfermedad(III o IV).
Transdisciplinary management of patients with disorders of sexual development in Colombia. Limiting factors for appropriate management..
La transición epitelio mesénquima (EMT) es un proceso compuesto de diferentes fases, donde una célula epitelial adquiere un fenotipo mesenquimal…
Lung cancer is the leading cause of cancer death in the world. The high mortality rate of this pathology is directly related to its late detection, since its symptoms can be masked by other diseases of lower risk
Lung cancer has a high mortality rate in men and women worldwide. Approximately 15% of diagnosed patients with this type of cancer do not exceed the 5-year survival rate
Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs
The anti-Müllerian hormone triggers the regression of uterus and fallopian tubes in male embryos; if there are problems in the synthesis or action of this protein, Müllerian structures persist in an otherwise phenotypic male.
Do I need Nature or Science papers for a successful career in science?
One of the unspoken rules in research is that a successful career in science is only possible with one or more papers with an impact factor above 10 or higher. This belief creates a lot of peer pressure among young scientists and may be even one of the causes of increasing numbers of scientific fraud cases. But is it true?
Writing an Abstract
An abstract is a 150- to 250-word paragraph that provides readers with a quick overview of your essay or report and its organization. It should express your thesis (or central idea) and your key points; it should also suggest any implications or applications of the research you discuss in the paper.