Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.

Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes.

Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus.

During hippocampal neuron differentiation, the expression of critical inducers of non-neuronal cell lineages must be efficiently silenced.

Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts.

Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified,…

Regulación epigenética en cáncer de pulmón: implicaciones para el clínico.

En el mundo, el cáncer de pulmón es la principal causa de muerte por neoplasias, yello se debe a que su detección ocurre en los estadios más avanzados de la enfermedad(III o IV).

Manejo transdisciplinario de pacientes con desórdenes del desarrollo sexual en Colombia. Limitantes para un manejo oportuno e integral.

Transdisciplinary management of patients with disorders of sexual development in Colombia. Limiting factors for appropriate management..

Transición epitelio mesénquima: de lo molecular a lo fisiológico.

La transición epitelio mesénquima (EMT) es un proceso compuesto de diferentes fases, donde una célula epitelial adquiere un fenotipo mesenquimal…

Gene dosage of DAX-1, determining in sexual differentiation: duplication of DAX-1 in two sisters with gonadal dysgenesis.

Sex determination refers to the sexual characteristics of an organism, male or female, based on the chromosomal and
genetic determinants.

Primary lung cancer cell culture from transthoracic needle biopsy samples.

Lung cancer is the leading cause of cancer death in the world. The high mortality rate of this pathology is directly related to its late detection, since its symptoms can be masked by other diseases of lower risk

Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoter.

Lung cancer has a high mortality rate in men and women worldwide. Approximately 15% of diagnosed patients with this type of cancer do not exceed the 5-year survival rate

RUNX family: Oncogenes or tumor suppressors (Review).

Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs

Novel homozygous mutation in a colombian patient with persistent müllerian duct syndrome: expanded phenotype.

The anti-Müllerian hormone triggers the regression of uterus and fallopian tubes in male embryos; if there are problems in the synthesis or action of this protein, Müllerian structures persist in an otherwise phenotypic male.

Disorders of Sexual Development: Current Status and Progress in the Diagnostic Approach.

Disorders of sexual development (DSD) are conditions with an atypical chromosomal, gonadal or phenotypic sex, which leads to differences in the development of the urogenital tract and different clinical phenotypes.

Disorders of sex development: Genetic characterization of a patient cohort.

Disorders of sex development (DSDs) are congenital conditions in which the external appearance of the individual does not coincide with the chromosomal constitution or the gonadal sex. In other words, there is an ambiguous or intermediate condition between the male and female phenotypes of the anatomical sex

Joint Transcriptomic Analysis of Lung Cancer and Other Lung Diseases.

Epidemiological and clinical evidence points cancer comorbidity with pulmonary chronic disease. The acquisition of some hallmarks of cancer by cells affected with lung pathologies as a cell adaptive mechanism to a shear stress, suggests that could be associated with the establishment of tumoral processes.

Control epigenético en la transición epitelio-mesénquima.

El proceso de transición epitelio-mesénquima (TEM) permite que una célula epitelial, de manera
temporal, adquiera un fenotipo mesenquimal como respuesta
a un estímulo interno o externo.

Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma.

Ewing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra‑osseous tissues, such as lung. The hallmark of ES tumors is a translocation between chromosomes 11 and 22, resulting in a fusion protein, commonly referred to as EWS‑FLI1. 

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

Hexanucleotide repeat expansions of the G4C2 motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

New findings in disorders of sex development: role of DMRT3 and OAS3.

We have read with great interest the study by Tsai et al. (1) in this issue of Fertility and Sterility, where the authors indicate that DMRT3 and OAS3 are involved in human disorders of sex development (DSD) by controlling ESR1 expression.

It´s on record that when a young aspirant asked Faraday the secret of his success as a scientific investigator, he replied: "The secret is comprised in three words - Work, Finish, Publish."
Michael Faraday

Do I need Nature or Science papers for a successful career in science?

One of the unspoken rules in research is that a successful career in science is only possible with one or more papers with an impact factor above 10 or higher. This belief creates a lot of peer pressure among young scientists and may be even one of the causes of increasing numbers of scientific fraud cases. But is it true?

Writing an Abstract

An abstract is a 150- to 250-word paragraph that provides readers with a quick overview of your essay or report and its organization. It should express your thesis (or central idea) and your key points; it should also suggest any implications or applications of the research you discuss in the paper.


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